PNAS, one of the world's most-cited and comprehensive multidisciplinary scientific journals, has published the research paper of Professor Yang Chengwei's team at SCNU's School of Life Sciences, entitled A SWI/SNF subunit regulates chromosomal dissociation of structural maintenance complex 5 during DNA repair in plant cells.


DNA repair is essential for accurate maintenance of genetic information in all types of cells, but what regulatory mechanisms act on the complexes involved in this process has been unclear. The structural maintenance complex 5/6 (SMC5/6) associates with chromosomes under normal conditions and is recruited to DNA double-strand breaks for repair. However, the mechanism by which this conserved complex becomes dissociated from its original chromosomal location during DNA repair is completely unknown. Given that knowledge, the current findings may provide hints for the study of DNA repair in other species.

Established in 1914, PNAS(Proceedings of the National Academy of the Sciences of the United States of America)is one of the world's four major scientific journals, namely Nature, Science, Cell and PNAS. Jiang Jieming, a postdoctoral fellow and Ma Ning, a master's student, at the School of Life Sciences South China Normal University, are the co-authors of the paper. Its co-corresponding authors are Professor Yang Chengwei and Associate Professor Lai Jianbin.

Source: the School of Life Sciences

Translated: Guo Xinyi

Proofread: Edwin Baak 

Reviewed: Li Jianru

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