2019-04-10
Likes

Dr. Shi Wenjun, team member with Professor Ying Guangguo at the Environmental Research Institute of South China Normal University (SCNU), published a research article "Dydrogesterone Causes Male Bias and Accelerates Sperm Maturation in Zebrafish (Danio rerio)" in the top international journal in environmental research "Environmental Science & Technology". The study found for the first time that long-term exposure to synthetic progestins dehydroprogesterone (DDG) can lead to masculinization in zebrafish. 

DDG is widely used in human oral contraceptives and in the treatment of irregular menstruation and endometriosis, as well as is widely detected in sewage treatment plants and surface water. DDG is generally considered to have a progesterone effect, but few people notice the androgenic effects of DDG.

2018080259bab4.jpg

Long-term exposure to dehydroprogesterone leads to masculinization in zebrafish

Dr. Shi Wenjun and his team members used zebrafish as a model organism to study the chronic effects of DDG on the sex differentiation and gonadal development of zebrafish using biological techniques and means such as gene chip technology, real-time PCR and tissue section. The results showed that after 120 days of exposure to DDG at 329 ng L-1, 98% of the fish were males, and the sperm maturation in zebrafish had been accelerated. Meanwhile, the study also explored the underlying mechanism of DDG-induced spermatogenesis in zebrafish. It was found that long-term exposure to low concentrations of DDG affects the sex differentiation of zebrafish by increasing the transcriptional expression levels of sex-related genes such as dmrt1, casp1b, casp3a and casp9 and decreasing the transcriptional expression level of cyp19a1a. The findings from this study demonstrate that DDG in the aquatic environment can cause male bias and accelerate sperm maturation in zebrafish, resulting in potential high ecological risks to fish populations.

20180802ee6d6a.jpg

Dehydroprogesterone promotes the synthesis of sperm acrosome in male fish

For reference:
Shi, W. J.; Jiang, Y. X.; Huang, G. Y.; Zhao, J. L.; Zhang, J. N.; Liu, Y. S.; Xie L.T.; Ying, G. G. Dydrogesterone causes male bias and accelerates sperm maturation in zebrafish (Danio rerio). Environ. Sci. Technol. 2018. DOI: 10.1021/acs.est.8b02556.


Source from Environmental Research Institute

Translated by Li Jianru

Proofread by Edwin Baak 



What to read next:

Associate Professor Dr. Fei Jifeng of the SCNU Institute for Brain Research and Rehabilitation Published a Paper in Nature
On January 24, Dr Fei Jifeng, Distinguished Young Talent of the Institute for Brain Research and Rehabilitation, South China Normal University and researchers from dozen scientific research institutes like Max Planck Institute of Molecular Cell Bi
Prof. Li Sheng and His Team Published Important Research Findings in Nature Communications
On March 20, the research paper titled “The genomic and functional landscapes of developmental plasticity in the American cockroach”, jointly written by Prof Li Sheng and his team from School of Life Sciences and Institute of Insect Science and Techn
SCNU Undergraduates of School of Chemistry and Environment Published Important Findings in《Angew. Chem. Int. Ed.》
Recently, members of the Innovation and Entrepreneurship Training Program of School of Chemistry and Environment of
New breakthrough in Video Electronic Paper in China
From May 21-25, 2018, the latest accomplishments in color video electronic paper displays manufactured by the team
Professor Xiang Hui Published Important Findings in Nature Ecology and Evolution
The research paper titled “The evolutionary road from wild moth to domestic silkworm” by Professor Xiang Hui fr
The Research Group of Researcher Jiang Feng of the SCNU Institute of Optoelectronic Materials and Technology Published Important Findings in the ACS Journal
Recently, the "Young Talent " of South China Normal University (SCNU) researcher Jiang Feng and his research group
Professor Lan Sheng’s Research Team Published a High-level Academic Paper in Nature Communications
Recently, the research team led by Prof Lan Sheng from the School of Information Optoelectronic Science and Engi
The School of Physics and Electronic Engineering publishes a high-level research paper on Quantum Science and Technology in Nature Photonics
The School of Physics and Electronic Engineering of SCNU has made important progress in quantum storage research:
Professor Ye Qi of the School of Mathematical Sciences, published a high-level Academic Paper in the Field of Applied Mathematics in Memoirs of the AMS
Recently, Prof Ye Qi, a new national talent recruited by the School of Mathematical Sciences of SCNU, and Prof